Statens Serum Institut

Microbiology and Infection Control

Niels Frimodt-Møller
Professor, MD, DMSc

Background and research interests: Niels Frimodt-Møller (NFM) is a physician with specialization in clinical microbiology (1988). In 2006 NFM became Adjunct Full Professor at Aarhus University. NFM has many years of experience in the field of clinical microbiological and antibiotic research as author of more than 250 peer-reviewed papers, several book chapters and more than 400 presentations at international congresses, meetings and symposia.  NFM is also reviewer and member of the editorial boards of numerous microbiological journals. NFM has been head of various departments and research groups at Statens Serum Institut since 1992. The research interests of NFM are antibiotic use, -pkpd, -dosing, -resistance, urinary tract infection and staphylococcal infections.

Role in DanCARD: Niels Frimodt-Møller is the head of the DanCARD project. 

Karen A. Krogfelt
Professor, MSc (Eng.), PhD

Background and research interests: Karen A. Krogfelt (KAK) graduated as a Master of Science in engineering, chemistry (Technical University of Denmark, DTU) in 1986 and PhD degree in 1989 and thereafter .post doc positions at the University of Rhode Island USA and at the University of Gothenborg, Sweden.
She was employed at Statens Serum Institut in 1991. In 2003, she was ap-pointed professor at BioCentrum, DTU in collaboration with SSI and in 2011 adjunct professor at the Department of Systems Biology, DTU. Karen A. Krogfelt is head of a research unit in Gastrointestinal Infections and Bacterial Serology, SSI. 
Karen A Krogfelt has participated in and organized international conferences and has published more than 150 articles in peer-reviewed journals and is also a reviewer and member of the editorial board of microbiological journals. She has supervised numerous bachelor and master’s students and has been the principal advisor for 25 Ph.D.-students.
Karen A. Krogfelt's main research activities focus on the pathogenic mechanisms related mainly to intestinal bacterial infections, as well as assessing the develop-ment of gut microbiota and its relation to pathogenesis. Mechanisms of bac-terial colonization, transmission from mother to infant as well as the role of microbiota in health and disease is in focus. Characterization of specific viru-lence factors involved in pathogenesis is used for the development of diag-nostic methods of bacterial infections.

Role in DanCARD: Karen A. Krogfelt will work on the development of models in the as-sessment of novel components for combating bacterial infections. Natural products will be exploited as sources or new antimicrobials. Mechanisms of resistance will be assessed.

Mette E. Skindersø
Post doc, MSc., PhD

Background and research interests: Mette Elena Skindersø graduated as Master of Science in Engineering, biotechnology (Technical University of Denmark, DTU) in 2004 and was awarded the Ph.D. degree in 2007  (also DTU). In her Ph.D. project she investigated host-pathogen interactions and immunomodulatory effectors using various techniques including DNA microarrays for whole genome expression and flow cytometry for surface marker profiling. Another focus area of her Ph.D. was the development of novel ways to counteract bacterial virulence and bacterial infection strategies by inhibition of key bacterial regulators. From 2008 to 2011 she worked as Research Scientist at ChemoMetec developing novel methods for image cytometry for use in immunology and cancer research.
She joined Statens Serum Institute and the DanCARD project in April 2011.
The research interests of Mette Elena Skindersø are immunology, host-pathogen interactions, cytometry, proteomics and transcriptomics.

Role in DanCARD: Mette Elena Skindersø will work with the design of both in vivo and in vitro based chronic wound models for infection and antimicrobial therapy studies. She will also investigate the antimicrobial peptides, enzymes and other products which have been isolated from secretions from maggots by transposon–assisted signal trapping (TAST) in collaboration with Novozymes.
(Enrolled 2010-2013)

Lotte Jakobsen
Post doc, MSc. (biology), PhD

Background and research interest: Lotte Jakobsen graduated at the Faculty of Biology at the University of Copenhagen, Denmark, in 2006. She recently received her PhD in Medicine from the Faculty of Health Science at Aarhus University, Copenhagen, in 2010. She now holds a post.doc. position at Statens Serum Institut working on DanCARD projects. Throughout her career, Lotte Jakobsen has  worked with molecular and clinical microbiology in relation to antimicrobial resistance research (mechanisms, development, transfer, persistence) and virulence with focus on extraintestinal Escherichia coli infections (especially urinary tract infections). Besides working with in vitro based approaches in this field of interest, she has worked with experimental animal models to investigate bacterial virulence as well as antimicrobial drug efficacy.

Role in DanCARD: Lotte Jakobsen will in close collaboration with the DanCARD partners design optimal treatment regimens for available antibiomicrobials as well as investigate the efficacy of novel drugs using various in vitro based tools as well as animal infection models. 
(Enrolled 2010-2012)

Anne Sandberg-Schaal
Coordinator, MSc. (pharmacy), PhD

Background and research interests: Anne Sandberg-Schaal (ASA) received her MSc in pharmacy from The Faculty of Pharmacy at the University of Copenhagen in 2005.  Subsequently she was employed at the Department of Microbiological Surveillance and Research at Statens Serum Institut first as research assistant and later as PhD student under the supervision of Niels Frimodt-Møller. In 2010 ASA received her PhD-degree in medicine from the Faculty of Health Science, Aarhus University. ASA is currently employed as coordinator of the DanCARD project situated at Statens Serum Institut.
ASA’s fields of interests are primarily the pharmacokinetic and -dynamic of antibiotics and Staphylococcus aureus infections with main focus on protein binding, dose-response relationships, intracellular infection and the impact on antimicrobial activity, mathematical modelling and PK/PD analysis. ASA handles both cell based in vitro models as well as experimental animal models.

Role in DanCARD: Anne Sandberg-Schaal is the coordinator of the DanCARD project and will be responsible for organising the annual meetings, the DanCARD website, annual reports and other administrative issues concerning the project. Further, ASA will collaborate with the other partners on selecting optimal dosing regimes for antimicrobial therapy (for both available and novel antibiotics designed in the DanCARD project) and also investigate the intracellular potential of theses drugs.
(Enrolled 2010-2013)

Karen Leth Nielsen
M. Sc. Eng (biotech), PhD

Background and research interests: Karen graduated in June 2008 as M.Sc. Eng. In biotechnology from the Technical University of Denmark. Subsequently she was employed at the department of Microbiology and Infection control at Statens Serum Institut as research assistant and later PhD student under the supervision of Niels Frimodt-Møller. She has defended her PhD thesis in June 2014, concerning pheno- and genotypic characterisation of faecal and urinary Escherichia coli, to the Faculty of Health at Aarhus University. Karen is currently employed as coordinator of the DanCARD project. The research interests of Karen Leth Nielsen are:

• Antimicrobial peptides
• Extraintestinal pathogenic E. coli
• Whole genome sequencing

Role in DanCARD: Karen Leth Nielsen is the coordinator of the DanCARD project and responsible for organizing the meetings, updating the DanCARD website, annual reports along with other administrative issues.

Last revised 15 July 2014